Abstract
Summary
The anticholinergic action of a group of glycolic acid esters was compared with their psychotomimetic potency in humans and their efficacy in producing centrally mediated behavioral disturbances in rats and mice. Although all of the effective psychotomimetic agents were potent anticholinergic agents, the agreement between the two frequently did not hold. The findings are in support of the idea that the glycolate esters may, at least in part, be acting directly at synaptic receptor sites and not necessarily by cholinergic blockade.
Get full access to this article
View all access options for this article.