Abstract
Summary
The uptake of probenecid by kidney cortex slices was examined over a 100-fold concentration range. This study offers direct evidence implicating tissue binding in the slice uptake process. For example, the steady-state accumulation conformed to a modified “Scatchard plot”. The data were interpreted to mean that two populations of binding sites exist. In addition it was shown that probenecid was bound by kidney cortex homogenates, but not by liver or renal medulla homogenates, an observation in keeping with slice uptake data reported previously.
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