Abstract
Summary
While normal cells of polymyxin-sensitive V. cholerae, polymyxin-resistant V. cholerae and V. eltor were found to exhibit a degree of resistance to polymyxin, increasing in that order, protoplasts of all 3 strains were sensitive to a polymyxin concentration insufficient to cause irreversible inhibition of growth of the normal vibrio cells. From the results it appears that the cell wall of El Tor vibrios differs in character from that of V. cholerae and this difference may be an important factor responsible for the resistance of V. eltor to polymyxin. Further, some other factor(s) in addition to the cell wall structure, such as a difference in the cell membrane of V. eltor from that of V. cholerae may contribute to the difference in the sensitivity of the two types of vibrios to polymyxin.
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