Abstract
Summary
Six glucocorticoids were administered separately to pregnant rabbits of one breed over a 4-day period preceding the time of normal palate closure. Triamcinolone, dexamethasone and prednisolone regularly produced cleft palates at several dose levels below that causing litter resorption. Cortisone and betamethasone induced cleft palate sporadically and methylprednisolone did not cause cleft palate formation at any of the dose levels tested. In a second breed of rabbit higher doses of triamcinolone were required to produce cleft palates than in the first breed.
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