Abstract
Summary
The hemodynamic response to rapid infusion of hypertonic mannitol was examined in 12 normotensive subjects. At osmolar clearances of 10 to 15 ml/min glomerular filtration rate was decreased in all, the maximal reduction ranging from 19.2 to 39.4%. The maximal reduction in effective renal blood flow was less than 10% in the majority of subjects. Extraction ratio for p-aminohippurate was unchanged in the 4 subjects in whom this measurement was made. The decrease in filtration rate which occurs during osmotic diuresis as induced by mannitol probably results, at least in part, from a reduction in net filtration pressure caused by increased tubular volume and hydrostatic pressure. It is recognized that changes in the interstitial pressure and renal vasomotor activity may also participate in the renal response to hypertonic mannitol infusion.
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