Abstract
Summary
In 10 subjects with liver disease and jaundice, and in one out of 2 hyperlipemic subjects, abnormalities in red cell phospholipid composition were found, consisting principally of elevation in percentage of Lec and decrease in percentage of P E, with lesser changes in P S and Sph. Total red cell lipid phosphorus ranged from normal to elevated. Fatty acids of red cell glycerophospholipids showed a variable pattern. Plasma phospholipids were abnormal in 11 out of 12 subjects. In one subject whose disease improved, plasma and red cell phospholipids returned to normal. The phospholipid composition of the erythrocyte membrane has thus been shown to correlate with changes in plasma phospholipids, while the fatty acids of the erythrocyte phospholipids show variability in composition.
Get full access to this article
View all access options for this article.