Abstract
Summary and Conclusions
Upon breathing 8% oxygen and 92% nitrogen, 10 puppies, 21-35 days of age, became severely hypoxic and developed partially compensated metabolic acidosis. Marked falls in plasma glycerol (.48 ± .16 μmole/ml, mean change ± S.D.) and FFA (.35 ± .15 μeq/ml) indicate that lipolysis was inhibited with hypoxia. It is suggested that products of anaerobic glycolysis contribute to the decreased FFA mobilization. Evidence implying that insulin is also involved is incomplete. Although diminished lipolysis may play a role in decreased heat and energy production in the severely hypoxic mammal, its relative importance needs to be resolved.
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