Abstract
Conclusions
Intravenous inoculation of a penicillin-resistant, phage type 80/81 staphylococcus caused lethal infection of all 7 untreated monkeys. Daily intragastric administration of 30-50 mg/kg of erythromycin, triacetyloleandomycin and cloxacillin was followed by mortalities in 7 of 8, 2 of 8 and 4 of 8, respectively. Thus, of the 2 bacteriostatic agents, triacetyloleandomycin was far superior to erythromycin as was cloxacillin, a bactericidal drug. Of particular interest was the observation that the bacteriostatic triacetyloleandomycin was as effective or perhaps superior to cloxacillin in preventing lethal infection.
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