Effect of Spontaneous Mammary Carcinogenesis on in vivo Glucose-U-C 14 Incorporation in C3H Mice. ∗

Abstract

Summary

Studies were conducted to elucidate previously observed differences between carcinogenic and noncarcinogenic mice. Glucose-U-C¹⁴ was incorporated into biochemical intermediates (lactic acid, glutamic acid, aspartic acid, and alpha-ketoglutaric acid) in C3H mice. These intermediates and glucose were isolated, and their concentration and specific activities were determined. For mammary tumor tissue versus liver, the in vivo incorporation of these intermediates indicated a decrease in oxidative metabolism via the Krebs cycle but no observable differences in glycolytic metabolism.