Abstract
Summary
Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.
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