Abstract
Summary
Using the isolated perfused rabbit kidney preparation, the relationship between proteinuria and albumin catabolism was studied in the absence of all other tissues and humoral substances of the body. The rate of breakdown of I131 screened rabbit albumin was studied in both the normal and the proteinuric perfused kidney. Proteinuria was produced in the normal perfused kidney by administration of renin or by elevation of the plasma protein concentration of the perfusion media. It was found that albumin catabolism was markedly increased in the perfused kidney during renin and protein loading proteinuria.
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