Abstract
Summary
The purine ribonucleotide reductases from a mouse tumor were studied in vitro. Adenylate and guanylate reductions were subject to end-product inhibition. β-D-arabinosylcytosine produced paradoxical inhibitory effects on deoxyadenylate biosynthesis. The adenylate reductase was stimulated by dGTP and guanylate reductase was stimulated by β-D-deoxythioguanylate.
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