Abstract
Summary
When given choice between water and 0.15 M NaCl solution to drink, rats treated with the diuretic agent, hydrochlorothiazide (0.3 and 0.6 g/kg food), for days or weeks increased their salt intake 70 to 150% above the level of controls while simultaneous water and food intakes were unaffected by treatment. Chronic administration of hydrochlorothiazide (0.6 g/kg food, 4 months) lowered the preference threshold of rats for NaCl solution from 0.029 to 0.010 mole/liter. This lowering of NaCl preference threshold by hydrochlorothiazide may be an important factor influencing the increased spontaneous NaCl intake of treated rats.
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