Abstract
Summary
Massive dosages of steroids have been administered subcutaneously and by diet to partially hepatectomized rats of either sex and the extent of liver regeneration ascertianed over a period of 10.5 days. Progesterone accelerated this process in both sexes and as tested in adult females, the effect could be antagonized by estrogen. High levels of injected anabolic steroids, methandrostenolone and norethanedrolone, stimulated regeneration in males but only the latter proved effective in the female under the specified conditions; in males, both agents were ineffective in diets at levels of 0.50%. Testosterone propionate, but not methyltestosterone, accelerated liver regeneration in the adult female, an effect which may involve potentiation by progesterone. Estrogen had no direct influence on the stimulation engendered by testosterone.
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