Abstract
Summary
Rabbit anti-rat placental serum is a potent teratogenic agent when injected into pregnant rats. It produces fetal growth retardation, fetal death and malformations. In these respects, it cannot be differentiated from rabbit anti-rat-kidney antiserum. Kidney and placental antisera have precipitin bands in common and the tissue antigens of kidney can protect against the effects of either antiserum. Although this cannot be stated with absolute certainty, it seems likely that there are one or more identical antibodies responsible for teratogenesis in kidney and placental antisera.
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