Inhibition of the Replication of a Bacterial DNA Virus by Chloroquine and Other 4-Aminoquinoline Drugs

Abstract

Summary

Chloroquine, a 4 aminoquinoline ‘antimalarial’ which binds to DNA, has been shown to inhibit replication of a DNA bacteriophage of E. coli under conditions where growth of the host continues. It is suggested that the ability of the drug to bind to DNA may account for this effect, but a more general metabolic effect cannot be ruled out.