Abstract
Summary
HAggIgG and Tg-antiTg complexes were labelled with I131 and injected into the peritoneum of rats. These rats were also injected IP with human IgM material, either containing, or free from, RF activity. Animals receiving aggregates plus RF-IgM showed much less radioactivity in the serum, liver, and spleen than controls, 3 hours after injection. Similar findings were noted in the complex-treated animals, except that no difference was noted in serum and evidence was obtained for extensive and rapid thyroglobulin breakdown. In aggregate-treated animals, qualitative differences were also noted in the serum on sucrose gradient centrifugation, suggesting another effect of RF-IgM on aggregate metabolism. Finally it was noted in vitro that extensive RF binding could occur in the Tg-antiTg system, a system which at the same time fixed complement very poorly, if at all.
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