Abstract
Summary
Tanned adult chicken erythro-cytes were found to adsorb rubella virus and there to be agglutinated by rubella antibody. Pre- and postimmunization sera were collected from guinea pigs and rabbits given live WM strain rubella virus grown in LLC-MK2 or BHK21 cells. Paired sera from human cases of rubella were also tested. In animals preim-munization titers were <2 and ranged from 64 to 2,048 postimmunization. Titers in convalescent humans ranged from 8 to 128. Significantly lesser increases in titer were seen with erythrocytes sensitized with uninfected tissue culture medium. Comparison of human hemagglutination (HA) and fluorescent antibody titers showed good agreement. HA titers varied with the infectivity titer of the sensitizing RV and HPV-77 strain RV reacted similarly.
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