Abstract
Summary
Offspring of mice inoculated during pregnancy with a Rauscher virus vaccine prepared from neoplastic spleen cell extracts were resistant to challenge with cells rendered myxonbrosarcomatous by transformation in vitro with the Rauscher virus. Offspring of mice similarly inoculated with normal spleen cell extracts showed no such resistance. The results suggest that cells transformed to a myxonbrosarcomatous pattern of growth by infection with the Rauscher leukemia virus in vitro share a specific antigen with spleen cell extracts rendered neoplastic by the same virus in vivo. The possible significance of the relationship between leukemia induction by the Rauscher virus in vivo and myxofibrosarcomatous transformation of cells by the same virus in vitro is discussed.
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