Abstract
Summary
Renal clearance and stop flow studies were done in dogs before and after infusion of diazoxide directly into the left renal artery. In all animals the left kidney showed a prompt diuresis, natriuresis and increase in creatinine or inulin clearance when diazoxide was given. No inhibition of distal tubular sodium reabsorption following diazoxide administration was found using the stop flow technique. The natriuresis produced by infusing diazoxide directly into the renal artery is probably due to renal vasodilation and resulting changes in intrarenal hemo-dynamics.
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