Abstract
Summary
Rats were fed a cholesterolemic diet which contained either 20% lard or corn oil. The blood lipid and cholesterol levels were appreciably lower in the rats fed diets containing an excess of PUFA. The livers of these rats had a higher cholesterol content but equal lipid and appreciably lower cholesterol activities than the group ingesting saturated fatty acids. Results suggest that a decreased rate of cholesterol synthesis occurs only after sufficient cholesterol has accumulated in the liver to inhibit its formation. The greater activities in the lipids of the intestinal and fatty tissue apparently were not promoting higher blood lipid levels. The activities of the cholesterol of both intestinal and fatty tissues were lower in the PUFA fed rats. Thus a decreased synthesis of cholesterol occurs in the liver as well as the intestinal tissue along with a slightly decreased content in the fatty tissues of rats fed a cholesterolemic diet containing large amounts of PUFA.
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