Abstract
Summary
Tests were performed on baseline and periodic blood samples obtained from rabbits treated with intramuscular injections of Triton WR-1339. The ensuing hyper-lipemia was characterized by marked elevation in total fatty acids, triglycerides, cholesterol, lipid phosphorus, and total lipids. Paper electrophoresis revealed a concomitant increase in β-lipoproteins. Lipid mobilizer (LM) also increased strikingly, as was determined indirectly by testing plasma aliquots for inhibition of heparin activated clearing lipase. On the basis of these and related studies, is is suggested that Triton hyper-lipemia is produced, at least in part, through sustained release of increased amounts of LM which mobilize triglycerides to the portal circulation. Furthermore, Triton modifies metabolic activity of the liver so that post-hepatic hyperphospholipidemia and hypercholester-emia ensue.
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