Immunoglobulin Classes of Serum Neutralizing Antibody Formed in Response to Infection with Human A 2 Influenza Virus

Abstract

Summary

In volunteers the sequential appearance of the immunoglobulin classes of neutralizing antibody formed as a result of infection with A₂/Bethesda/10/63 influenza was studied. The antibody appeared in the IgG class and no significant antibody in the IgM or IgA classes was found. It was particularly notable that no IgM antibody could be detected 7 days after inoculation. The pattern of antibody against A₂/Japan/305/57 was nearly identical to that formed against the inoculum strain. Antibody rises were also noted against A/PR8 and A₁/FM1 influenza viruses.