Abstract
Summary
Rats were separated into 2 groups—long-sleepers and short-sleepers—on the basis of their response to a dose of hexo-barbital. The drug-metabolizing activities of the hepatic postmitochondrial supernatant fraction from long-sleepers were less than those from short-sleepers with respect to hexo-barbital, acetanilide, aminopyrine, and o-nitro-anisole, each of which represents a different drug-metabolism pathway. This trend was observed in all 5 strains of rats examined. After phenobarbital pretreatment, this difference between the two groups was no longer observed in one strain studied. The strain differences in drug-metabolism activities were not as great in the rat as those reported in various rabbit strains.
Get full access to this article
View all access options for this article.