Abstract
Summary
A series of experiments has been presented in which it was shown that crude extracts of human plasma contain a material that stimulates villous motility. It was not possible to distinguish a difference between the activities of crude mucosal, plasma, and urine preparations although it was suggested that there may be concentration differences.
Refined preparations of villikinin showed a similarity to mucosal and urine extracts in activity as well as mobility. However, it was not possible to demonstrate antivillikinin in preparations other than those from intestinal mucosa. The activity of villikinin was different from that produced by histamine, 5-hydroxytryptamine and bradykinin. It is felt that the data presented clearly demonstrate the presence of villikinin in the plasma and that plasma villikinin is similar to mucosal and urovillikinin.
The authors wish to thank Mr. David Alford and Mr. Philip Arnold for their technical assistance in the performance of the experiments.
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