Metabolism of Puromycin Aminonucleoside in the Normal,“Pre-Nephrotic,” and Nephrotic Rat. ∗

Abstract

Summary

Approximately 80% of injected aminonucleoside-8-C¹⁴ is excreted in the urine and feces within 24 hrs by the rat. The principal urinary products are unchanged amino-nucleoside, the monodemethylated analog, and allantoin. Daily administration of aminonu-cleoside for 12 days did not influence the course of its own metabolism.