Abstract
Summary
Two enterovirus-like agents were isolated in human amnion (FL line) cells from rectal swabs taken from healthy children during a longterm epidemiological study of viral infection in a semi-closed community during 1960-61. Of the first type (Hu 504), 26 representatives were isolated, of the second (Hu 659), 175. Both viruses were shown to exhibit the properties typical of human Cox-sackie A type enteroviruses. They were shown to exhibit the properties typical of human Coxsackie A type enteroviruses. They were shown to be prime strains of Coxsackie A Type 17 virus, with no apparent (Hu 504) or erratic (Hu 659) pathogenicity for suckling mice. Serological studies in a normal population group from the Pittsburgh area failed to show the presence of antibodies against either of these viruses. No conclusion can be drawn concerning the pathogenicity of these viruses for humans. The Mill virus, isolated by Murphy in Australia in 1963 from children suffering with acute diarrhea, appears to be identical with the Hu 659 virus.
The expert technical assistance of Miss Dianna Bellas and Miss Eileen Torretti is gratefully acknowledged.
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