Abstract
Summary
Experimental allergic encephalo-myelitis (AE) and adjuvant arthritis (AA) were induced in male Lewis rats. 6-Mercapto-purine and cortisone inhibited both AE and AA, but phenylbutazone and aspirin were effective only in AA. The different effects of these immunosuppressive and anti-inflammatory drugs on clinical signs, organ and body weights, and hematologic changes in AE and AA suggest either that the pathogenesis of the two models is dissimilar or that the acute inflammatory response is of greater etiological importance in arthritis. AE and AA should be useful for differentiating the im-munosuppressive and anti-inflammatory activities of drugs.
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