Abstract
Summary
The distribution of histamine and mast cells in the fundic, corporal and antral mucosa of the canine stomach was assayed. Twelve areas from each of 4 stomachs were studied. Mast cell profiles of these areas showed the cell population to be similar in all mucosal areas, although the greatest number of cells occurred deeper in the glandular mucosa of the antrum than in the glandular mucosa of the fundus and corpus. In contrast, the amount of histamine in the antral mucosa (73.3 ± 4.9 μg/g) was roughly one half of that noted in fundic and corporal mucosa (133.6 ± 1.4 μg/g), a difference which is statistically significant, (p<.05). One possible explanation for these observations is that the major portion of corporal and fundic histamine is not associated with mast cells.
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