Abstract
Summary
Individual follicles, with their enclosed oocytes, were dissected from the ovary of the leopard frog, Rana pipiens, and their response to steroid hormones studied. Biologically and chemically related substance, progesterone, pregnenolone and 11-deoxycorticosterone, were most effective in producing germinal vesicle breakdown. Removal of the follicular tissue did not prevent the action of the steroid progesterone on the germinal vesicle. Steroids appear to act directly on the oocyte and calcium ions appear to be important for the biological action of the steroids.
The author wishes to express his sincere appreciation to The Upjohn Co. for the support which greatly aided this study. The efforts of Dr. Albert Notation in preparation of sulfated steroids are also acknowledged.
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