Abstract
Summary
Cell mediated immunity against homologous SV40 tumor cells was demonstrable in the homologous in vivo hamster system but not in cell culture. The effectiveness of exudate cells from immunized hamsters was clearly influenced by the ratio of target cells to immune cells and by the age of test hamsters used with protective effect demonstrable in adult but not in 1 week-old hamsters. High levels of immunity against homologous tumor were also demonstrable by direct subcutaneous challenge. The latter system was desirable for assay of vaccine potency because of simplicity and rapidity of obtaining results.
The authors are indebted to W. Clark and E. Glenn for technical assistance. The irradiation was carried out at Albert Einstein Medical Center, Philadelphia, through the courtesy of Dr. Jacob Gershon-Cohen with the kind assistance of Dr. David Sklaroff.
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