Abstract
Summary
Following intranasal inoculation with rhinovirus NIH 1059, 9 of 9 volunteers developed a respiratory infection and 7 of 9 had illness ranging from mild rhinitis to febrile upper respiratory tract disease. Only 1 of many stool and rectal swab specimens from these men yielded rhinovirus. No detectable intestinal infection occurred in 3 volunteers who received NIH 1059 in enteric-coated capsules, nor in 5 volunteers inoculated directly into the duodenal lumen via Rehfuss small intestinal tube. Effects of gasitric and duodenal secretions, trypsin, and body temperature (37°C) on growth and survival of NIH 1059 were tested in vitro, and their role in preventing intestinal infection and excretion of rhinoviruses evaluated.
Gratitude is expressed to the following: Miss Joan C. Enterline, Mr. Holly Smith, and Mr. Leonard P. Durocher, for technical assistance; Mr. Franklyn Gray, Assistance Supervisor, Normal Volunteer Program, Clinical Center, National Institutes of Health, and officials of the Bureau of Prisons, Department of Justice, for materially aiding the program; and the men who volunteered to be subjects, for their excellent cooperation.
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