Abstract
Summary
Prior stimulation of the reticulo-endothelial system (RES) with zymosan and glucan markedly altered plasma acid phos-phatase and plasma beta glucuronidase activity during subsequent hemorrhagic shock in the rat. There was an increase in the plasma activity of both hydrolases during the hy-potensive period in glucan-injected and saline-injected animals compared to uninjected shocked controls; the increase in zymosan-treated animals was substantially less than that after glucan or saline. Hemorrhagic shock caused small increases in total acid phos-phatase and beta glucuronidase activities of large-granule fractions of liver homogenates in control and saline-injected animals but a decrease in zymosan-treated animals. Un-sedimentable activity of acid phosphatase and beta glucuronidase in the large-granule fractions of liver was increased in all groups after 3 hours of hypotension. It is suggested that the marked differences in hydrolase activation in zymosan and glucan rats may be due to enzyme binding or membrane permeability properties and that the lesser release of hy-drolytic enzymes may be a characteristic feature of the shocked-protective action of zymosan.
The authors are pleased to acknowledge the helpful comments of Dr. Julian Van Lancker of Brown University in preparation of this manuscript.
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