Abstract
Summary
Guinea pigs pretreated with un-fractionated carrageenan subcutaneously exhibited a sensitization reaction when challenged 3, 5 or 8 weeks later with the same polysaccharide. The same phenomenon occurred in guinea pigs pretreated and challenged with lambda carrageenan, the active fraction for stimulation of connective tissue growth. Granulomas from sensitized animals were consistently larger, and had significantly lower collagen concentrations than granulomas from animals pretreated with saline. Total protein, dry defatted solids, and iron concentrations were not significantly altered, but a two-fold increase in granuloma weight indicated a large increase in these elements, and especially in non-collagenous protein synthesis.
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