Abstract
Summary
The effect of various doses of angiotensin II on adrenocortical secretion of aldosterone and 17-hydroxycorticoids was determined in dogs fed a low sodium diet for 14 days and in control dogs. The increments in aldosterone secretion produced by angiotensin II in the animals fed the low sodium diet were greater than the corresponding increments in controls. No changes in the increments in 17-hydroxycorticoids or blood pressure were observed.
Angiotensin II (1-L-asparaginyl-5-L-valyl angiotensin octapeptide) was provided by Ciba Pharmaceutical Co., Summit, N. J. ACTH was provided by Upjohn Co., and Lonalac for preparation of low sodium diets by Mead Johnson Co. We wish to thank Mr. Roy Shackelford and Miss Margaret Saari for technical assistance.
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