Abstract
Summary
Sublethal whole-body X-irradi-ation of the guinea pig before or after respiratory vaccination with normally innocuous P. tularensis LVS may result in death. No evidence of a change from a self-limiting to a fulminating type of infection was obtained. Irradiated vaccinated animals produced ag-glutinin titers only slightly lower than nonir-radiated controls. Only a small decrease in resistance to tularemia was observed between surviving irradiated vaccinees and nonir-radiated vaccinees.
We wish to acknowledge the collaboration of Lt. Colonel Joshua Henderson in the X-irradiation procedures and of Dr. Joseph V. Jemski in the aerogenic vaccination exposures.
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