Abstract
Summary
The activities of 3 liver enzymes : glucose-6-phosphatase, fructose-1,6-diphosphatase, and pyruvate kinase were studied in thyroidectomized and hyperthyroid rats. Thyroidectomy considerably decreased all 3 activities. Thyroxine treatment resulted in an increase of glucose- 6-phosphatase activity but caused decrease in fructose-l?6-diphosphatase activity of normal animals and no change in pyruvate kinase activity of thyroidectomized animals. This contradictory picture has been discussed as thyroxine causing no increase in gluconeogenesis. The specific increases in glucose-6-phosphatase activity may be explained by the increased synthesis of microsomal protein on thyroxine treatment.
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