Effect of Mercuhydrin Alone and in Conjunction with Ammonium Chloride On Radiostrontium Excretion in Man. ∗

Abstract

Summary

The diuresis induced by intramuscular injections of mercuhydrin at varying time intervals following intravenous or oral administration of Sr⁸⁵ was associated with an inconsistent and only slight increase in urinary Sr⁸⁵ excretion despite a concomitant increase in urinary calcium excretion. Following the discontinuation of mercuhydrin there was marked inhibition of the urinary excretion of Sr⁸⁵ and calcium. Further increase in urine volume induced by mercuhydrin used in conjunction with ammonium chloride resulted in a marked increase in urinary calcium but not in further enhancement of Sr⁸⁵ excretion. Mercuhydrin actually diminished the effect of ammonium chloride by inhibiting radiostrontium excretion following discontinuation of this combined therapy. This rebound inhibition of Sr⁸⁵ excretion contrasts with the sustained increase in Sr⁸⁵ and calcium excretion following the discontinuation of ammonium chloride.