Abstract
Summary
The effect of pituitary and gonadal hormones on Friend Virus Disease in mice has been studied. Estradiol inhibited the virus-induced hypervolemic polycythemia, hepatomegaly, and splenomegaly. The effect was most evident during the second week following injection. Progesterone, adrenocor-ticotropic hormone, and testosterone did not influence significantly the hematologic and organ changes characterizing the disease. A possible mechanism of action of estrogen-induced suppressions of erythropoiesis in this disease is discussed.
We extend thanks to Dr. P. Trudel, and to Edmund Dywinksi, Andres Bulba, Joyce Jividen, Ruth Deck-ert, Basilius Sywenkyj, A. G. Miramd, and W. Trudel.
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