Abstract
Summary
Polyoma virus-induced complement-fixing antigen (PV-ICFA) has been demonstrated by immunofluorescence in polyoma primary rat kidney and hamster subcutaneous fibrosarcomas, in one polyoma trans-plantable mouse tumor and in one polyoma-transformed in vitro hamster cell line. The antigen has a typical nuclear localization appearing either in a granular or in a diffused form throughout the whole nucleus except for the nucleoli. A lower concentration of ICFA was found in the hamster tumors than in the rat and mouse tumors. The PV-ICFA was also demonstrated in polyoma-infected mouse, hamster, and rat embryonic tissue cultures. In primary infected cultures of all three species, the synthesis of PV-ICFA preceded that of viral antigen (PV-A). Many more cells synthesized PV-ICFA than PV-A, The difference was especially high in the hamster and the rat cultures in which the ratio of PV-ICFA to PV-A positive cells averaged about forty.
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