Abstract
Summary
Erythrocyte glucokinase and glucose-6-phosphate dehydrogenase activities, glucose concentration, and tolerances to glucose and tolbutamide were measured in 6 adult sheep and 4 lambs growing from 1 to 150 days. The young lambs had G6PD activity and tolerances like normal man. The adult sheep had low G6PD activities and tolerances like diabetic man. Erythrocyte G6PD and glucose diminished gradually in growing lambs to approximate adult values by 60-100 days. The changes in the tolerances tests can be explained by a progressive development of insulin resistance, previously demonstrated in growing lambs.
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