Abstract
Summary
Rats were exposed to two different dose levels of CC14 by inhalation while on a normal diet or one deficient in choline for 2 or 4 weeks. The lipid and hydroxyproline content and the histology of the livers were studied. Anti-liver factors were determined by hemagglutination and precipitin methods and skin tests utilizing extracts prepared from normal and CC4-exposed rats. Choline deficiency produced the greatest lipidosis in the liver and was associated with a high prevalence of anti-liver serum factors by hemagglutination. Under the conditions of these experiments, CC14 did little to influence these parameters.
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