Effect of Radiation Plus Endotoxin on the Walker 256 Rat Carcinosarcoma. ∗

Abstract

Summary

A dose of 1500 R X-ray to rat Walker carcinosarcoma 256, followed by a sublethal dose of endotoxin, produced routinely a condition that gross and histological study suggested was an infarct involving all or nearly all tumor tissue. Tracer studies with intravenously administered I¹³¹ antibody to rat fibrin showed a pronounced localization of radioactivity about the periphery of treated tumors with no radioactivity in the central portions of the tumor, a picture consistent with a lack of blood circulation there. X-ray or endotoxin, administered alone, at the same doses, produced no obvious effect on tumor histology or antibody localization.