Abstract
Summary
Pregnant rats were given single injections of nicotinamide (NAM) (8-100 mg/kg body wt) before or after a teratogenic dose of the vitamin antimetabolite 6-amino-nicotinamide (6-AN) late in gestation. NAM effectively competed with 6-AN in preventing cleft palate when given 2 hours before, simultaneously, or up to 2 hours after antimetabolite treatment. However, vitamin replacement therapy was unable to prevent palatal abnormalities or restrict the action of 6-AN to specific time periods when given 12-24 hours before or 2-72 hours after 6-AN administration.
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