Abstract
Summary
A method for demonstrating vascular leakage, utilizing colloidal iron-dextran, was applied in the study of experimental cholera in infant rabbits. An increase of vascular permeability, delayed in onset and prolonged in duration, consistent with the clinical course of cholera was demonstrated in this model. The reaction resembled histamine-mediated responses in that it involved primarily the post capillary venule. However the time course differed from the usual immediate-type histamine reaction. It is suggested that this permeability alteration is a major factor in experimental choleraic diarrhea. It may be possible to test this hypothesis in human cholera with the technique described.
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