Abstract
Discussion and summary
The pharmaco-logic antagonism between the isomers is striking. It appears that each isomer is competing for its respective receptor site, namely, the convulsive or anesthetic site. In the “balanced state” the action of one is nullified by the other, and an apparently normal animal results.
Not any of the physicochemical properties or measurements conducted on the isomers, flurothyl and ISO, revealed a marked difference which might be considered responsible for their respective pharmacologic responses. The surfactant phenomenon was not a constant finding with all fluorinated, convulsive ethers. We were unable to establish any relationship between this physical property and pharmacologic response; however, it was sufficiently unusual and interesting to warrant exploration.
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