Abstract
Summary
The alkaline phosphomonoes-terase activity of several mouse tissues and serum has been investigated in uninfected controls and animals infected with Diplo-coccus pneumoniae. No significant change of enzymatic activity was found in kidney, lung, sternum, femur, and spleen. As the infection progressed a decrease in activity was observed in the liver enzyme, while a marked increase occurred in small intestine. The enzymatic activity of the serum also increased during infection, but less strikingly. In organ-specific inhibition experiments it was shown that serum and intestinal enzyme behaved identically. The data support the concept that a major portion of serum AP may originate in the small intestine. Neither the infection-related increase in intestinal AP nor the fall in hepatic AP was dependent upon an intact adrenal gland in the presence of circulating glucocorticoid hormones.
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