Abstract
Summary
Stimulation of hemolytic plaque formation by rat spleen cells after primary immunization was produced by in vitro incubation of these cells with chlorpromazine, promethazine and thioridazine in 2 X 10−3 M concentration. This effect may be the result of increased cell membrane permeability produced by these compounds. The phe-nothiazine derivatives may be useful agents for increasing the sensitivity of the hemolytic paque procedure by enhancing the release of antibody from immunized cells.
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