Abstract
Summary
Potassium-depleted rats excrete a consistently greater fraction of filtered urea than control animals at virtually all urine osmolalities and relative and absolute rates of water excretion. Furthermore, despite the reduction in Urine : Plasma inulin ratios to values below 2, no animals excreted urine that was hypotonic to plasma. The data suggest that in potassium depletion there is either a diminished permeability of the collecting tubule to water and/or urea, or inhibition of a transfer system whereby urea is re-absorbed from the collecting tubule against a concentration gradient.
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