Abstract
Summary
In 2 out of 4 subjects ingesting breakfast containing 27.3 g of fat, a transient increase of the L-phenylalanine-sensitive “intestinal” alkaline phosphatase isoen-zyme occurred in the serum. In 4 out of 4 subjects ingesting breakfast with higher fat content (69.6 g) the rise appeared and persisted for 4 hours. Individuals differed greatly in the pattern of serum enzyme partition which were exhibited. Fat absorption is linked with the later appearance in the serum of the L-phenylalanine-sensitive isoenzyme of alkaline phosphatase.
Note Added in Proof: A recent interesting report by Langman et al (Nature, 1966, v212, 41) describes the relevance of the genetic background to the extent of fat-induced increases in serum “intestinal” alkaline phosphatase.
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